Predicted to be involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and type B pancreatic cell proliferation. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BTBD10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BTBD10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BTBD10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:13,276,893–13,279,144 | 185.6 kb | Distal (>10kb) Multiome | 718 | |
| chr11:13,462,425–13,464,206 | 22 bp | At TSS Multiome | 858 | |
| chr11:13,468,848–13,469,071 | 5.7 kb | Proximal (<10kb) | 15 | |
| chr11:13,487,045–13,487,538 | 24.1 kb | Distal (>10kb) Multiome | 325 | |
| chr11:13,606,521–13,607,137 | 143.6 kb | Distal (>10kb) Multiome | 85 | |
| chr11:13,667,826–13,669,520 | 205.2 kb | Distal (>10kb) Multiome | 653 |
Genomic view of the BTBD10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.