Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BSN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BSN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BSN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:49,276,912–49,277,398 | 277.4 kb | Distal (>10kb) Multiome | 291 | |
| chr3:49,339,607–49,340,853 | 214.3 kb | Distal (>10kb) Multiome | 1044 | |
| chr3:49,357,868–49,359,083 | 196.0 kb | Distal (>10kb) Multiome | 908 | |
| chr3:49,411,409–49,412,844 | 142.4 kb | Distal (>10kb) Multiome | 899 | |
| chr3:49,422,179–49,422,905 | 131.9 kb | Distal (>10kb) Multiome | 453 | |
| chr3:49,428,857–49,429,869 | 125.0 kb | Distal (>10kb) Multiome | 712 | |
| chr3:49,461,484–49,462,134 | 92.7 kb | Distal (>10kb) Multiome | 207 | |
| chr3:49,468,926–49,470,930 | 84.3 kb | Distal (>10kb) Multiome | 919 | |
| chr3:49,539,369–49,540,584 | 14.5 kb | Distal (>10kb) Multiome | 628 | |
| chr3:49,553,618–49,555,244 | 3 bp | At TSS Multiome | 710 | |
| chr3:49,718,116–49,720,106 | 165.2 kb | Distal (>10kb) Multiome | 450 | |
| chr3:49,723,361–49,724,517 | 169.6 kb | Distal (>10kb) Multiome | 769 | |
| chr3:49,785,831–49,787,202 | 232.1 kb | Distal (>10kb) Multiome | 854 | |
| chr3:49,802,203–49,804,006 | 248.4 kb | Distal (>10kb) Multiome | 733 |
Genomic view of the BSN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.