Enables several functions, including ATP binding activity; ATPase binding activity; and magnesium ion binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of insulin secretion involved in cellular response to glucose stimulus. Located in centrosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BRSK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRSK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRSK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:1,262,536–1,263,097 | 127.5 kb | Distal (>10kb) Multiome | 577 | |
| chr11:1,308,732–1,310,441 | 80.6 kb | Distal (>10kb) Multiome | 890 | |
| chr11:1,336,825–1,337,928 | 53.5 kb | Distal (>10kb) Multiome | 223 | |
| chr11:1,382,728–1,383,562 | 7.1 kb | Proximal (<10kb) Multiome | 442 | |
| chr11:1,388,152–1,391,242 | 564 bp | At TSS Multiome | 551 | |
| chr11:1,546,495–1,547,275 | 156.5 kb | Distal (>10kb) Multiome | 395 | |
| chr11:1,568,160–1,568,834 | 178.2 kb | Distal (>10kb) Multiome | 58 | |
| chr11:1,571,981–1,572,819 | 182.0 kb | Distal (>10kb) Multiome | 410 | |
| chr11:1,573,992–1,574,943 | 184.4 kb | Distal (>10kb) Multiome | 379 |
Genomic view of the BRSK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.