Enables magnesium ion binding activity and protein serine/threonine kinase activity. Involved in mitotic G2 DNA damage checkpoint signaling and protein phosphorylation. Acts upstream of or within G2/M transition of mitotic cell cycle; peptidyl-serine phosphorylation; and response to UV. Located in cell junction; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BRSK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRSK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRSK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:55,062,536–55,063,406 | 220.8 kb | Distal (>10kb) Multiome | 586 | |
| chr19:55,069,129–55,069,807 | 214.5 kb | Distal (>10kb) Multiome | 288 | |
| chr19:55,080,038–55,082,744 | 202.4 kb | Distal (>10kb) Multiome | 639 | |
| chr19:55,086,246–55,087,525 | 196.9 kb | Distal (>10kb) Multiome | 258 | |
| chr19:55,091,780–55,093,292 | 191.7 kb | Distal (>10kb) Multiome | 208 | |
| chr19:55,095,398–55,095,977 | 188.2 kb | Distal (>10kb) Multiome | 90 | |
| chr19:55,117,134–55,119,109 | 166.3 kb | Distal (>10kb) Multiome | 881 | |
| chr19:55,146,210–55,148,117 | 137.1 kb | Distal (>10kb) Multiome | 528 | |
| chr19:55,156,193–55,157,266 | 127.4 kb | Distal (>10kb) Multiome | 317 | |
| chr19:55,160,567–55,161,360 | 123.2 kb | Distal (>10kb) Multiome | 554 | |
| chr19:55,165,952–55,167,256 | 117.3 kb | Distal (>10kb) Multiome | 719 | |
| chr19:55,173,717–55,174,287 | 109.9 kb | Distal (>10kb) Multiome | 330 | |
| chr19:55,178,876–55,179,477 | 104.9 kb | Distal (>10kb) Multiome | 479 | |
| chr19:55,216,490–55,217,227 | 67.1 kb | Distal (>10kb) Multiome | 1077 | |
| chr19:55,257,751–55,259,635 | 24.8 kb | Distal (>10kb) Multiome | 1054 | |
| chr19:55,279,599–55,280,933 | 3.7 kb | Proximal (<10kb) Multiome | 805 | |
| chr19:55,283,835–55,284,716 | 56 bp | At TSS Multiome | 242 | |
| chr19:55,301,640–55,302,240 | 18.0 kb | Distal (>10kb) Multiome | 448 | |
| chr19:55,338,676–55,340,358 | 55.6 kb | Distal (>10kb) Multiome | 882 | |
| chr19:55,340,675–55,341,535 | 57.4 kb | Distal (>10kb) Multiome | 368 | |
| chr19:55,353,720–55,354,487 | 70.1 kb | Distal (>10kb) Multiome | 297 | |
| chr19:55,369,099–55,370,447 | 86.0 kb | Distal (>10kb) Multiome | 383 | |
| chr19:55,383,539–55,384,553 | 99.9 kb | Distal (>10kb) Multiome | 374 | |
| chr19:55,384,697–55,386,560 | 101.7 kb | Distal (>10kb) Multiome | 903 | |
| chr19:55,406,950–55,408,675 | 124.1 kb | Distal (>10kb) Multiome HiCAR | 965 | |
| chr19:55,452,738–55,453,308 | 169.1 kb | Distal (>10kb) Multiome | 339 | |
| chr19:55,460,784–55,462,230 | 177.8 kb | Distal (>10kb) Multiome | 947 | |
| chr19:55,476,048–55,477,307 | 192.7 kb | Distal (>10kb) Multiome | 1007 | |
| chr19:55,484,846–55,485,682 | 201.2 kb | Distal (>10kb) Multiome | 594 | |
| chr19:55,503,638–55,504,310 | 220.0 kb | Distal (>10kb) Multiome | 710 | |
| chr19:55,516,768–55,517,459 | 233.1 kb | Distal (>10kb) Multiome | 583 | |
| chr19:55,536,923–55,537,366 | 253.2 kb | Distal (>10kb) Multiome | 180 | |
| chr19:55,549,822–55,550,343 | 266.1 kb | Distal (>10kb) Multiome | 396 | |
| chr19:55,580,080–55,581,090 | 296.8 kb | Distal (>10kb) Multiome | 718 |
Genomic view of the BRSK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.