Transcription factors with Perturb-seq knockdown data for BRPF3-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRPF3-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRPF3-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:35,920,112–35,921,529 | 276.1 kb | Distal (>10kb) Multiome | 965 | |
| chr6:36,027,295–36,028,609 | 169.5 kb | Distal (>10kb) Multiome | 1031 | |
| chr6:36,130,184–36,131,324 | 66.7 kb | Distal (>10kb) Multiome HiCAR | 615 | |
| chr6:36,196,013–36,197,672 | 687 bp | At TSS Multiome | 825 | |
| chr6:36,284,908–36,285,433 | 88.0 kb | Distal (>10kb) Multiome | 104 | |
| chr6:36,360,373–36,360,968 | 163.4 kb | Distal (>10kb) Multiome | 348 | |
| chr6:36,368,910–36,369,452 | 172.0 kb | Distal (>10kb) Multiome | 68 | |
| chr6:36,423,143–36,423,810 | 226.2 kb | Distal (>10kb) Multiome | 886 | |
| chr6:36,442,626–36,443,451 | 245.8 kb | Distal (>10kb) Multiome | 982 |
Genomic view of the BRPF3-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.