The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BRMS1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRMS1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRMS1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:34,693,166–34,693,989 | 1133.1 kb | Distal (>10kb) Multiome HiCAR | 463 | |
| chr14:35,533,170–35,535,985 | 292.5 kb | Distal (>10kb) Multiome | 1111 | |
| chr14:35,808,576–35,809,453 | 17.3 kb | Distal (>10kb) Multiome | 901 | |
| chr14:35,818,465–35,818,619 | 7.8 kb | Proximal (<10kb) | 161 | |
| chr14:35,821,935–35,822,107 | 4.3 kb | Proximal (<10kb) | 285 | |
| chr14:35,825,879–35,827,210 | 37 bp | At TSS Multiome | 1095 |
Genomic view of the BRMS1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.