This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BRMS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRMS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRMS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:66,045,170–66,045,637 | 299.8 kb | Distal (>10kb) Multiome | 394 | |
| chr11:66,048,912–66,049,460 | 295.9 kb | Distal (>10kb) Multiome | 83 | |
| chr11:66,051,716–66,052,760 | 292.9 kb | Distal (>10kb) Multiome | 901 | |
| chr11:66,069,690–66,071,102 | 275.0 kb | Distal (>10kb) Multiome | 622 | |
| chr11:66,256,991–66,258,893 | 87.2 kb | Distal (>10kb) Multiome | 844 | |
| chr11:66,266,650–66,269,501 | 77.6 kb | Distal (>10kb) Multiome | 869 | |
| chr11:66,277,646–66,278,447 | 67.0 kb | Distal (>10kb) Multiome | 363 | |
| chr11:66,282,288–66,283,017 | 62.5 kb | Distal (>10kb) Multiome | 618 | |
| chr11:66,288,772–66,289,992 | 55.7 kb | Distal (>10kb) Multiome | 944 | |
| chr11:66,311,658–66,313,958 | 32.9 kb | Distal (>10kb) Multiome | 1005 | |
| chr11:66,316,861–66,317,347 | 28.0 kb | Distal (>10kb) Multiome | 164 | |
| chr11:66,328,223–66,328,781 | 16.6 kb | Distal (>10kb) Multiome | 662 | |
| chr11:66,344,804–66,345,488 | 30 bp | At TSS Multiome | 731 | |
| chr11:66,347,078–66,348,463 | 2.7 kb | Proximal (<10kb) Multiome | 866 | |
| chr11:66,370,733–66,372,576 | 26.7 kb | Distal (>10kb) Multiome | 800 | |
| chr11:66,408,467–66,409,206 | 63.6 kb | Distal (>10kb) Multiome | 569 | |
| chr11:66,421,258–66,422,129 | 76.7 kb | Distal (>10kb) Multiome | 1190 | |
| chr11:66,438,544–66,439,241 | 93.9 kb | Distal (>10kb) Multiome | 756 | |
| chr11:66,466,155–66,467,634 | 121.7 kb | Distal (>10kb) Multiome | 579 | |
| chr11:66,479,578–66,480,947 | 135.3 kb | Distal (>10kb) Multiome | 937 | |
| chr11:66,510,277–66,510,954 | 165.5 kb | Distal (>10kb) Multiome | 787 | |
| chr11:66,545,631–66,547,072 | 201.1 kb | Distal (>10kb) Multiome | 753 | |
| chr11:66,568,061–66,568,910 | 223.4 kb | Distal (>10kb) Multiome | 392 | |
| chr11:66,592,561–66,593,452 | 248.0 kb | Distal (>10kb) Multiome | 857 | |
| chr11:66,616,078–66,617,408 | 271.4 kb | Distal (>10kb) Multiome | 1011 | |
| chr11:66,637,919–66,639,003 | 293.4 kb | Distal (>10kb) Multiome | 872 |
Genomic view of the BRMS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.