The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for BRAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:2,313,875–2,314,819 | 241.2 kb | Distal (>10kb) Multiome | 684 | |
| chr7:2,353,760–2,355,437 | 201.0 kb | Distal (>10kb) Multiome | 1060 | |
| chr7:2,403,048–2,404,583 | 152.2 kb | Distal (>10kb) Multiome | 775 | |
| chr7:2,451,319–2,452,043 | 104.1 kb | Distal (>10kb) Multiome | 660 | |
| chr7:2,518,679–2,520,557 | 36.0 kb | Distal (>10kb) Multiome HiCAR | 567 | |
| chr7:2,555,131–2,556,097 | 50 bp | At TSS Multiome | 772 | |
| chr7:2,558,641–2,559,572 | 3.3 kb | Proximal (<10kb) Multiome | 669 | |
| chr7:2,631,170–2,632,859 | 76.1 kb | Distal (>10kb) Multiome | 658 | |
| chr7:2,646,545–2,647,390 | 91.4 kb | Distal (>10kb) Multiome HiCAR | 245 | |
| chr7:2,688,023–2,688,723 | 132.6 kb | Distal (>10kb) Multiome | 176 | |
| chr7:2,706,487–2,707,069 | 151.2 kb | Distal (>10kb) Multiome | 81 | |
| chr7:2,709,414–2,710,178 | 154.2 kb | Distal (>10kb) Multiome | 481 | |
| chr7:2,821,232–2,821,746 | 265.8 kb | Distal (>10kb) Multiome | 210 | |
| chr7:2,843,825–2,845,052 | 288.8 kb | Distal (>10kb) Multiome | 635 |
Genomic view of the BRAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.