BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BPNT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BPNT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BPNT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:219,834,079–219,834,880 | 255.3 kb | Distal (>10kb) Multiome HiCAR | 136 | |
| chr1:219,839,143–219,840,267 | 250.0 kb | Distal (>10kb) Multiome | 246 | |
| chr1:220,045,998–220,046,836 | 43.3 kb | Distal (>10kb) Multiome | 976 | |
| chr1:220,086,269–220,086,448 | 3.3 kb | Proximal (<10kb) | 126 | |
| chr1:220,089,552–220,090,573 | 130 bp | At TSS Multiome | 779 | |
| chr1:220,093,676–220,094,911 | 4.3 kb | Proximal (<10kb) Multiome | 815 | |
| chr1:220,271,709–220,273,089 | 182.6 kb | Distal (>10kb) Multiome | 984 | |
| chr1:220,338,584–220,339,585 | 249.1 kb | Distal (>10kb) Multiome | 180 |
Genomic view of the BPNT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.