Involved in lysosome localization and organelle transport along microtubule. Located in cytoplasmic side of lysosomal membrane; plasma membrane; and plus-end kinesin complex. Part of BORC complex. Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BORCS5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BORCS5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BORCS5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:12,266,376–12,267,615 | 89.9 kb | Distal (>10kb) Multiome | 1095 | |
| chr12:12,349,790–12,350,566 | 6.8 kb | Proximal (<10kb) Multiome | 671 | |
| chr12:12,356,841–12,357,808 | 47 bp | At TSS Multiome | 912 | |
| chr12:12,561,525–12,563,261 | 205.7 kb | Distal (>10kb) Multiome HiCAR | 768 | |
| chr12:12,611,502–12,612,657 | 254.8 kb | Distal (>10kb) Multiome | 980 | |
| chr12:12,693,129–12,694,039 | 336.5 kb | Distal (>10kb) Multiome HiCAR | 190 | |
| chr12:12,695,955–12,697,008 | 339.3 kb | Distal (>10kb) Multiome HiCAR | 568 | |
| chr12:12,716,729–12,717,910 | 360.2 kb | Distal (>10kb) Multiome HiCAR | 799 |
Genomic view of the BORCS5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.