This gene encodes a protein that reduces cell growth by stimulating apoptosis. Alternative splicing and the use of alternative promoters result in multiple transcript variants encoding the same protein. This gene is imprinted in brain where different transcript variants are expressed from each parental allele. Transcript variants initiating from the upstream promoter are expressed preferentially from the maternal allele, while transcript variants initiating downstream of the interspersed NNAT gene (GeneID:4826) are expressed from the paternal allele. Transcripts at this locus may also undergo A to I editing, resulting in amino acid changes at three positions in the N-terminus of the protein. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for BLCAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BLCAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BLCAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:37,289,329–37,289,991 | 238.2 kb | Distal (>10kb) Multiome HiCAR | 1018 | |
| chr20:37,319,185–37,319,833 | 208.4 kb | Distal (>10kb) Multiome | 87 | |
| chr20:37,345,682–37,346,478 | 181.8 kb | Distal (>10kb) Multiome | 557 | |
| chr20:37,396,207–37,397,008 | 131.3 kb | Distal (>10kb) Multiome HiCAR | 227 | |
| chr20:37,520,318–37,521,734 | 6.6 kb | Proximal (<10kb) Multiome | 237 | |
| chr20:37,527,439–37,528,617 | 132 bp | At TSS Multiome | 899 | |
| chr20:37,534,500–37,534,700 | 6.6 kb | Proximal (<10kb) | 280 | |
| chr20:37,564,323–37,564,876 | 36.7 kb | Distal (>10kb) Multiome | 440 | |
| chr20:37,693,635–37,694,526 | 166.1 kb | Distal (>10kb) Multiome | 809 |
Genomic view of the BLCAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.