This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for BIN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BIN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BIN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:126,885,475–126,887,048 | 220.8 kb | Distal (>10kb) Multiome | 524 | |
| chr2:126,971,341–126,972,649 | 135.1 kb | Distal (>10kb) Multiome | 617 | |
| chr2:127,024,615–127,026,056 | 82.1 kb | Distal (>10kb) Multiome | 462 | |
| chr2:127,049,850–127,050,796 | 57.0 kb | Distal (>10kb) Multiome | 428 | |
| chr2:127,105,209–127,108,284 | 1.6 kb | Proximal (<10kb) Multiome | 594 | |
| chr2:127,293,716–127,294,914 | 186.9 kb | Distal (>10kb) Multiome | 876 | |
| chr2:127,386,971–127,388,844 | 280.1 kb | Distal (>10kb) Multiome | 986 |
Genomic view of the BIN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.