Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BHLHE40-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BHLHE40-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BHLHE40-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:4,867,666–4,869,297 | 111.4 kb | Distal (>10kb) Multiome | 812 | |
| chr3:4,975,994–4,976,641 | 3.7 kb | Proximal (<10kb) Multiome | 525 | |
| chr3:4,976,933–4,980,833 | 973 bp | At TSS Multiome | 1341 | |
| chr3:4,980,934–4,981,061 | 973 bp | At TSS | 89 | |
| chr3:4,984,003–4,984,509 | 4.0 kb | Proximal (<10kb) | 420 | |
| chr3:4,985,756–4,987,513 | 6.0 kb | Proximal (<10kb) Multiome | 1151 | |
| chr3:4,988,795–4,989,138 | 8.8 kb | Proximal (<10kb) | 319 | |
| chr3:5,001,877–5,002,834 | 22.5 kb | Distal (>10kb) Multiome | 452 | |
| chr3:5,016,164–5,017,130 | 36.7 kb | Distal (>10kb) Multiome | 672 | |
| chr3:5,017,970–5,018,615 | 38.3 kb | Distal (>10kb) Multiome | 294 | |
| chr3:5,026,091–5,027,285 | 47.0 kb | Distal (>10kb) Multiome | 782 | |
| chr3:5,122,077–5,123,401 | 143.0 kb | Distal (>10kb) Multiome | 1009 | |
| chr3:5,186,712–5,189,316 | 207.6 kb | Distal (>10kb) Multiome | 891 | |
| chr3:5,213,036–5,214,091 | 233.7 kb | Distal (>10kb) Multiome | 200 |
Genomic view of the BHLHE40-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.