Transcription factors with Perturb-seq knockdown data for BHLHE22-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BHLHE22-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BHLHE22-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:64,567,706–64,568,094 | 9.3 kb | Proximal (<10kb) | 113 | |
| chr8:64,575,150–64,576,578 | 848 bp | At TSS | 212 | |
| chr8:64,577,016–64,578,817 | at TSS | At TSS | 362 | |
| chr8:64,579,671–64,582,347 | 2.2 kb | Proximal (<10kb) | 477 | |
| chr8:64,585,340–64,586,287 | 7.9 kb | Proximal (<10kb) | 47 | |
| chr8:64,586,989–64,587,617 | 9.6 kb | Proximal (<10kb) | 72 |
Genomic view of the BHLHE22-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.