Predicted to enable DNA binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BEND7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BEND7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BEND7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:13,299,293–13,300,384 | 229.0 kb | Distal (>10kb) Multiome | 850 | |
| chr10:13,302,089–13,302,853 | 226.6 kb | Distal (>10kb) Multiome | 807 | |
| chr10:13,347,195–13,348,918 | 180.9 kb | Distal (>10kb) Multiome | 753 | |
| chr10:13,349,410–13,350,393 | 179.1 kb | Distal (>10kb) Multiome | 432 | |
| chr10:13,351,365–13,351,877 | 177.5 kb | Distal (>10kb) Multiome | 105 | |
| chr10:13,440,173–13,440,755 | 88.5 kb | Distal (>10kb) Multiome | 414 | |
| chr10:13,528,519–13,529,578 | 53 bp | At TSS Multiome | 267 | |
| chr10:13,536,624–13,537,051 | 7.6 kb | Proximal (<10kb) | 286 | |
| chr10:13,586,728–13,587,229 | 57.9 kb | Distal (>10kb) Multiome | 812 | |
| chr10:13,690,233–13,691,095 | 161.6 kb | Distal (>10kb) Multiome | 202 | |
| chr10:13,707,398–13,707,910 | 178.6 kb | Distal (>10kb) Multiome | 353 |
Genomic view of the BEND7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.