This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for BCL2L13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCL2L13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCL2L13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:17,366,817–17,367,342 | 271.8 kb | Distal (>10kb) Multiome | 186 | |
| chr22:17,368,390–17,370,790 | 269.6 kb | Distal (>10kb) Multiome | 494 | |
| chr22:17,379,144–17,379,660 | 259.4 kb | Distal (>10kb) Multiome | 126 | |
| chr22:17,628,467–17,629,189 | 10.0 kb | Proximal (<10kb) Multiome | 714 | |
| chr22:17,638,195–17,639,235 | 88 bp | At TSS Multiome | 934 | |
| chr22:17,773,581–17,774,636 | 135.3 kb | Distal (>10kb) Multiome | 486 | |
| chr22:17,921,809–17,922,254 | 283.4 kb | Distal (>10kb) Multiome | 99 |
Genomic view of the BCL2L13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.