This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for BCL2L12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCL2L12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCL2L12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:49,403,611–49,404,247 | 262.0 kb | Distal (>10kb) Multiome | 305 | |
| chr19:49,432,343–49,432,785 | 233.4 kb | Distal (>10kb) Multiome | 103 | |
| chr19:49,436,149–49,436,821 | 229.5 kb | Distal (>10kb) Multiome | 248 | |
| chr19:49,441,067–49,441,861 | 224.5 kb | Distal (>10kb) Multiome | 223 | |
| chr19:49,442,072–49,444,054 | 223.0 kb | Distal (>10kb) Multiome | 914 | |
| chr19:49,451,347–49,452,239 | 214.1 kb | Distal (>10kb) Multiome | 764 | |
| chr19:49,452,723–49,453,850 | 212.6 kb | Distal (>10kb) Multiome | 847 | |
| chr19:49,476,063–49,476,551 | 189.6 kb | Distal (>10kb) Multiome | 244 | |
| chr19:49,487,027–49,488,279 | 178.5 kb | Distal (>10kb) Multiome | 964 | |
| chr19:49,495,613–49,496,661 | 169.7 kb | Distal (>10kb) Multiome | 919 | |
| chr19:49,500,403–49,501,353 | 165.2 kb | Distal (>10kb) Multiome | 405 | |
| chr19:49,512,565–49,513,700 | 152.9 kb | Distal (>10kb) Multiome | 655 | |
| chr19:49,527,651–49,528,221 | 138.0 kb | Distal (>10kb) Multiome | 354 | |
| chr19:49,533,232–49,534,476 | 131.9 kb | Distal (>10kb) Multiome | 534 | |
| chr19:49,555,629–49,557,180 | 109.8 kb | Distal (>10kb) Multiome | 294 | |
| chr19:49,580,125–49,580,813 | 85.3 kb | Distal (>10kb) Multiome | 848 | |
| chr19:49,589,601–49,594,008 | 72.4 kb | Distal (>10kb) Multiome | 994 | |
| chr19:49,638,063–49,638,728 | 27.7 kb | Distal (>10kb) Multiome | 237 | |
| chr19:49,639,671–49,642,787 | 25.5 kb | Distal (>10kb) Multiome | 1067 | |
| chr19:49,664,165–49,665,096 | 1.4 kb | Proximal (<10kb) Multiome | 679 | |
| chr19:49,665,345–49,666,430 | 41 bp | At TSS Multiome | 721 | |
| chr19:49,672,105–49,672,787 | 6.4 kb | Proximal (<10kb) Multiome | 625 | |
| chr19:49,675,666–49,675,902 | 9.7 kb | Proximal (<10kb) | 84 | |
| chr19:49,676,058–49,678,754 | 11.0 kb | Distal (>10kb) Multiome | 1033 | |
| chr19:49,680,433–49,681,147 | 14.8 kb | Distal (>10kb) Multiome | 435 | |
| chr19:49,690,485–49,691,761 | 25.2 kb | Distal (>10kb) Multiome | 327 | |
| chr19:49,746,188–49,746,748 | 80.5 kb | Distal (>10kb) Multiome | 283 | |
| chr19:49,766,231–49,767,440 | 100.7 kb | Distal (>10kb) Multiome | 718 | |
| chr19:49,802,146–49,802,787 | 136.5 kb | Distal (>10kb) Multiome | 200 | |
| chr19:49,805,226–49,805,871 | 139.6 kb | Distal (>10kb) Multiome | 245 | |
| chr19:49,808,201–49,809,746 | 143.0 kb | Distal (>10kb) Multiome | 509 | |
| chr19:49,812,926–49,813,834 | 147.5 kb | Distal (>10kb) Multiome | 650 | |
| chr19:49,817,356–49,818,721 | 152.3 kb | Distal (>10kb) Multiome | 784 | |
| chr19:49,850,394–49,852,067 | 184.9 kb | Distal (>10kb) Multiome | 862 | |
| chr19:49,866,817–49,868,124 | 201.4 kb | Distal (>10kb) Multiome | 874 | |
| chr19:49,869,068–49,870,398 | 203.7 kb | Distal (>10kb) Multiome | 832 | |
| chr19:49,875,842–49,878,576 | 211.8 kb | Distal (>10kb) Multiome | 1153 | |
| chr19:49,889,853–49,891,381 | 224.5 kb | Distal (>10kb) Multiome | 640 | |
| chr19:49,928,884–49,930,473 | 264.0 kb | Distal (>10kb) Multiome | 1141 |
Genomic view of the BCL2L12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.