BAZ1B

bromodomain adjacent to zinc finger domain 1B | WSTF, WBSCR10, WBSCR9

This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008]

Member of: DE-6 DE-6.3

Biological processes 35 terms

DNA damage response (GO:0006974)DNA damage response (GO:0006974)DNA damage response (GO:0006974)WICH complex (GO:0090535)WICH complex (GO:0090535)chromatin (GO:0000785)chromatin remodeling (GO:0006338)chromatin remodeling (GO:0006338)chromatin remodeling (GO:0006338)chromatin remodeling (GO:0006338)chromatin remodeling (GO:0006338)condensed chromosome (GO:0000793)histone H2AXY142 kinase activity (GO:0140801)histone H2AXY142 kinase activity (GO:0140801)histone binding (GO:0042393)histone binding (GO:0042393)histone kinase activity (GO:0035173)negative regulation of mitotic chromosome condensation (GO:1905213)negative regulation of mitotic chromosome condensation (GO:1905213)non-membrane spanning protein tyrosine kinase activity (GO:0004715)nuclear replication fork (GO:0043596)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)pericentric heterochromatin (GO:0005721)positive regulation of transcription by RNA polymerase I (GO:0045943)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase III (GO:0045945)post-translational protein modification (GO:0043687)protein binding (GO:0005515)protein tyrosine kinase activity (GO:0004713)regulation of transcription by RNA polymerase II (GO:0006357)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating BAZ1B 0 TFs

Transcription factors with Perturb-seq knockdown data for BAZ1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BAZ1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to BAZ1B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BAZ1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:73,324,142–73,324,594	197.9 kb	Distal (>10kb) Multiome	226
chr7:73,423,745–73,424,470	98.1 kb	Distal (>10kb) Multiome	298
chr7:73,433,411–73,434,685	88.5 kb	Distal (>10kb) Multiome	614
chr7:73,521,449–73,522,945	173 bp	At TSS Multiome	977
chr7:73,556,852–73,558,145	35.1 kb	Distal (>10kb) Multiome	1080
chr7:73,578,111–73,579,357	56.5 kb	Distal (>10kb) Multiome	765
chr7:73,612,552–73,613,365	90.7 kb	Distal (>10kb) Multiome	733
chr7:73,622,785–73,623,555	100.8 kb	Distal (>10kb) Multiome	659
chr7:73,623,956–73,624,915	102.3 kb	Distal (>10kb) Multiome	652
chr7:73,647,765–73,648,318	125.7 kb	Distal (>10kb) Multiome	506
chr7:73,667,449–73,668,409	145.5 kb	Distal (>10kb) Multiome	678
chr7:73,682,807–73,684,039	161.2 kb	Distal (>10kb) Multiome	803
chr7:73,703,674–73,704,431	181.8 kb	Distal (>10kb) Multiome	226
chr7:73,719,255–73,720,191	197.4 kb	Distal (>10kb) Multiome	478
chr7:73,734,760–73,735,432	212.6 kb	Distal (>10kb) Multiome	592
chr7:73,738,048–73,739,612	216.7 kb	Distal (>10kb) Multiome	949
chr7:73,741,460–73,743,811	220.8 kb	Distal (>10kb) Multiome	604
chr7:73,769,598–73,771,029	248.2 kb	Distal (>10kb) Multiome	496

Genome Browser

Genomic view of the BAZ1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.