Transcription factors with Perturb-seq knockdown data for BASP1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BASP1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BASP1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:16,935,234–16,937,118 | 280.2 kb | Distal (>10kb) Multiome | 661 | |
| chr5:17,065,548–17,066,750 | 150.4 kb | Distal (>10kb) Multiome | 241 | |
| chr5:17,154,067–17,154,914 | 62.2 kb | Distal (>10kb) Multiome | 223 | |
| chr5:17,216,144–17,219,338 | 165 bp | At TSS Multiome | 753 | |
| chr5:17,335,827–17,336,709 | 119.6 kb | Distal (>10kb) Multiome | 169 | |
| chr5:17,402,218–17,402,989 | 185.8 kb | Distal (>10kb) Multiome | 206 | |
| chr5:18,368,677–18,369,760 | 1152.5 kb | Distal (>10kb) Multiome HiCAR | 26 |
Genomic view of the BASP1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.