Transcription factors with Perturb-seq knockdown data for BALR6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BALR6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BALR6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:17,741,727–17,743,491 | 270.9 kb | Distal (>10kb) Multiome | 1058 | |
| chr3:17,840,550–17,841,652 | 172.4 kb | Distal (>10kb) Multiome | 408 | |
| chr3:17,846,059–17,847,000 | 167.0 kb | Distal (>10kb) Multiome | 65 | |
| chr3:18,018,594–18,019,918 | 5.6 kb | Proximal (<10kb) Multiome | 282 | |
| chr3:18,201,034–18,202,125 | 187.9 kb | Distal (>10kb) Multiome | 185 | |
| chr3:18,233,890–18,235,270 | 221.0 kb | Distal (>10kb) Multiome | 193 | |
| chr3:18,294,917–18,295,844 | 281.8 kb | Distal (>10kb) Multiome | 290 |
Genomic view of the BALR6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.