BAG6

BAG cochaperone 6 | D6S52E, G3, Scythe, BAT3

This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Developmental clusters: GC7 GC7 GC2 GC2

Biological processes 72 terms

BAT3 complex (GO:0071818)BAT3 complex (GO:0071818)ERAD pathway (GO:0036503)ERAD pathway (GO:0036503)ERAD pathway (GO:0036503)ERAD pathway (GO:0036503)Hsp70 protein binding (GO:0030544)NK T cell activation (GO:0051132)apoptotic process (GO:0006915)brain development (GO:0007420)brain development (GO:0007420)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)endoplasmic reticulum stress-induced pre-emptive quality control (GO:0061857)extracellular exosome (GO:0070062)extracellular region (GO:0005576)identical protein binding (GO:0042802)immune response-activating cell surface receptor signaling pathway (GO:0002429)internal peptidyl-lysine acetylation (GO:0018393)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)kidney development (GO:0001822)kidney development (GO:0001822)lung development (GO:0030324)lung development (GO:0030324)maintenance of unfolded protein (GO:0036506)membrane (GO:0016020)membrane (GO:0016020)misfolded protein binding (GO:0051787)misfolded protein binding (GO:0051787)molecular adaptor activity (GO:0060090)natural killer cell activation (GO:0030101)negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)negative regulation of proteolysis (GO:0045861)negative regulation of proteolysis (GO:0045861)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)polyubiquitin modification-dependent protein binding (GO:0031593)polyubiquitin modification-dependent protein binding (GO:0031593)polyubiquitin modification-dependent protein binding (GO:0031593)positive regulation of ERAD pathway (GO:1904294)post-translational protein targeting to endoplasmic reticulum membrane (GO:0006620)proteasomal protein catabolic process (GO:0010498)proteasome binding (GO:0070628)proteasome binding (GO:0070628)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein carrier activity (GO:0140597)protein stabilization (GO:0050821)protein stabilization (GO:0050821)receptor ligand activity (GO:0048018)regulation of apoptotic process (GO:0042981)regulation of embryonic development (GO:0045995)regulation of embryonic development (GO:0045995)regulation of protein stability (GO:0031647)ribosome binding (GO:0043022)signaling receptor binding (GO:0005102)spermatogenesis (GO:0007283)spermatogenesis (GO:0007283)synaptonemal complex assembly (GO:0007130)synaptonemal complex assembly (GO:0007130)tail-anchored membrane protein insertion into ER membrane (GO:0071816)ubiquitin protein ligase binding (GO:0031625)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-specific protease binding (GO:1990381)

Expression (TPM)

TFs regulating BAG6 0 TFs

Transcription factors with Perturb-seq knockdown data for BAG6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BAG6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to BAG6

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BAG6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:31,366,884–31,367,398	285.6 kb	Distal (>10kb) Multiome	433
chr6:31,399,631–31,400,231	252.8 kb	Distal (>10kb) Multiome	678
chr6:31,403,046–31,404,269	249.1 kb	Distal (>10kb) Multiome	796
chr6:31,441,682–31,442,105	210.8 kb	Distal (>10kb) Multiome	316
chr6:31,462,703–31,463,323	189.6 kb	Distal (>10kb) Multiome	352
chr6:31,497,638–31,498,615	154.6 kb	Distal (>10kb) Multiome	613
chr6:31,541,205–31,542,816	110.6 kb	Distal (>10kb) Multiome	1073
chr6:31,546,485–31,547,136	105.9 kb	Distal (>10kb) Multiome	589
chr6:31,547,301–31,547,742	105.0 kb	Distal (>10kb) Multiome	762
chr6:31,580,713–31,581,330	71.6 kb	Distal (>10kb) Multiome	745
chr6:31,619,744–31,621,435	32.1 kb	Distal (>10kb) Multiome	1127
chr6:31,651,682–31,653,297	29 bp	At TSS Multiome	1113
chr6:31,660,325–31,660,941	8.2 kb	Proximal (<10kb) Multiome	892
chr6:31,664,725–31,666,373	12.2 kb	Distal (>10kb) Multiome	1039
chr6:31,682,887–31,683,880	30.7 kb	Distal (>10kb) Multiome	248
chr6:31,702,816–31,703,520	50.6 kb	Distal (>10kb) Multiome	875
chr6:31,713,576–31,714,641	61.5 kb	Distal (>10kb) Multiome	171
chr6:31,728,852–31,730,814	77.6 kb	Distal (>10kb) Multiome	979
chr6:31,739,236–31,740,741	87.3 kb	Distal (>10kb) Multiome	1043
chr6:31,766,045–31,766,778	113.8 kb	Distal (>10kb) Multiome	351
chr6:31,795,097–31,796,366	143.3 kb	Distal (>10kb) Multiome	979
chr6:31,806,162–31,807,183	154.3 kb	Distal (>10kb) Multiome	947
chr6:31,814,125–31,815,936	162.0 kb	Distal (>10kb) Multiome	822
chr6:31,818,020–31,818,663	165.7 kb	Distal (>10kb) Multiome	280
chr6:31,821,306–31,822,544	169.4 kb	Distal (>10kb) Multiome	714
chr6:31,826,770–31,828,135	174.9 kb	Distal (>10kb) Multiome	1000
chr6:31,834,277–31,835,371	182.1 kb	Distal (>10kb) Multiome	1085
chr6:31,862,148–31,864,173	210.3 kb	Distal (>10kb) Multiome	1118
chr6:31,896,965–31,898,037	244.9 kb	Distal (>10kb) Multiome	654
chr6:31,901,114–31,902,643	249.6 kb	Distal (>10kb) Multiome	826
chr6:33,547,185–33,548,324	1895.1 kb	Distal (>10kb) Multiome HiCAR	155

Genome Browser

Genomic view of the BAG6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.