This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for B4GAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = B4GAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of B4GAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:66,048,912–66,049,460 | 298.5 kb | Distal (>10kb) Multiome | 83 | |
| chr11:66,051,716–66,052,760 | 295.4 kb | Distal (>10kb) Multiome | 901 | |
| chr11:66,069,690–66,071,102 | 277.5 kb | Distal (>10kb) Multiome | 622 | |
| chr11:66,256,991–66,258,893 | 89.7 kb | Distal (>10kb) Multiome | 844 | |
| chr11:66,266,650–66,269,501 | 80.1 kb | Distal (>10kb) Multiome | 869 | |
| chr11:66,277,646–66,278,447 | 69.5 kb | Distal (>10kb) Multiome | 363 | |
| chr11:66,282,288–66,283,017 | 65.0 kb | Distal (>10kb) Multiome | 618 | |
| chr11:66,288,772–66,289,992 | 58.3 kb | Distal (>10kb) Multiome | 944 | |
| chr11:66,311,658–66,313,958 | 35.5 kb | Distal (>10kb) Multiome | 1005 | |
| chr11:66,316,861–66,317,347 | 30.5 kb | Distal (>10kb) Multiome | 164 | |
| chr11:66,328,223–66,328,781 | 19.1 kb | Distal (>10kb) Multiome | 662 | |
| chr11:66,344,804–66,345,488 | 2.5 kb | Proximal (<10kb) Multiome | 731 | |
| chr11:66,347,078–66,348,463 | 182 bp | At TSS Multiome | 866 | |
| chr11:66,370,733–66,372,576 | 24.2 kb | Distal (>10kb) Multiome | 800 | |
| chr11:66,408,467–66,409,206 | 61.1 kb | Distal (>10kb) Multiome | 569 | |
| chr11:66,421,258–66,422,129 | 74.1 kb | Distal (>10kb) Multiome | 1190 | |
| chr11:66,438,544–66,439,241 | 91.3 kb | Distal (>10kb) Multiome | 756 | |
| chr11:66,466,155–66,467,634 | 119.2 kb | Distal (>10kb) Multiome | 579 | |
| chr11:66,479,578–66,480,947 | 132.7 kb | Distal (>10kb) Multiome | 937 | |
| chr11:66,510,277–66,510,954 | 163.0 kb | Distal (>10kb) Multiome | 787 | |
| chr11:66,545,631–66,547,072 | 198.5 kb | Distal (>10kb) Multiome | 753 | |
| chr11:66,568,061–66,568,910 | 220.9 kb | Distal (>10kb) Multiome | 392 | |
| chr11:66,592,561–66,593,452 | 245.4 kb | Distal (>10kb) Multiome | 857 | |
| chr11:66,616,078–66,617,408 | 268.9 kb | Distal (>10kb) Multiome | 1011 | |
| chr11:66,637,919–66,639,003 | 290.9 kb | Distal (>10kb) Multiome | 872 |
Genomic view of the B4GAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.