This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants using multiple alternate promoters have been observed for this gene. [provided by RefSeq, Sep 2017]
Transcription factors with Perturb-seq knockdown data for B3GALT5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = B3GALT5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of B3GALT5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:39,312,364–39,314,680 | 299.1 kb | Distal (>10kb) Multiome | 1121 | |
| chr21:39,348,209–39,350,114 | 263.7 kb | Distal (>10kb) Multiome | 923 | |
| chr21:39,380,111–39,380,888 | 232.6 kb | Distal (>10kb) Multiome | 663 | |
| chr21:39,387,404–39,389,039 | 225.3 kb | Distal (>10kb) Multiome | 713 | |
| chr21:39,445,343–39,446,179 | 167.1 kb | Distal (>10kb) Multiome | 837 | |
| chr21:39,451,559–39,452,036 | 161.2 kb | Distal (>10kb) Multiome | 267 | |
| chr21:39,610,768–39,610,998 | 1.9 kb | Proximal (<10kb) | 109 | |
| chr21:39,612,590–39,613,211 | 96 bp | At TSS Multiome | 208 | |
| chr21:41,316,576–41,317,164 | 1703.9 kb | Distal (>10kb) Multiome HiCAR | 233 |
Genomic view of the B3GALT5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.