The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021]
Transcription factors with Perturb-seq knockdown data for AXL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AXL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AXL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:41,175,862–41,176,466 | 43.0 kb | Distal (>10kb) Multiome | 330 | |
| chr19:41,192,831–41,193,504 | 26.0 kb | Distal (>10kb) Multiome | 377 | |
| chr19:41,218,771–41,219,447 | 182 bp | At TSS Multiome | 345 | |
| chr19:41,226,202–41,226,599 | 7.0 kb | Proximal (<10kb) | 700 | |
| chr19:41,262,152–41,262,839 | 43.2 kb | Distal (>10kb) Multiome | 787 | |
| chr19:41,262,983–41,265,249 | 44.9 kb | Distal (>10kb) Multiome | 1022 | |
| chr19:41,309,685–41,310,764 | 91.0 kb | Distal (>10kb) Multiome | 1016 | |
| chr19:41,324,382–41,326,571 | 106.0 kb | Distal (>10kb) Multiome | 670 | |
| chr19:41,351,173–41,351,794 | 132.2 kb | Distal (>10kb) Multiome | 465 | |
| chr19:41,352,533–41,354,401 | 134.8 kb | Distal (>10kb) Multiome | 807 | |
| chr19:41,363,475–41,364,733 | 144.9 kb | Distal (>10kb) Multiome | 774 | |
| chr19:41,376,421–41,376,995 | 157.5 kb | Distal (>10kb) Multiome | 379 | |
| chr19:41,397,079–41,398,056 | 178.3 kb | Distal (>10kb) Multiome | 849 | |
| chr19:41,406,970–41,407,622 | 188.1 kb | Distal (>10kb) Multiome | 88 | |
| chr19:41,426,905–41,428,213 | 208.3 kb | Distal (>10kb) Multiome | 512 | |
| chr19:41,439,463–41,440,163 | 220.6 kb | Distal (>10kb) Multiome | 765 |
Genomic view of the AXL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.