Acts upstream of or within positive regulation of proteolysis. Located in mitochondrial matrix and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AURKAIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AURKAIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AURKAIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:1,079,478–1,080,558 | 295.2 kb | Distal (>10kb) Multiome | 746 | |
| chr1:1,115,769–1,117,022 | 259.0 kb | Distal (>10kb) Multiome | 743 | |
| chr1:1,157,424–1,158,362 | 217.6 kb | Distal (>10kb) Multiome | 575 | |
| chr1:1,200,907–1,201,739 | 173.8 kb | Distal (>10kb) Multiome | 430 | |
| chr1:1,231,448–1,233,390 | 143.1 kb | Distal (>10kb) Multiome | 884 | |
| chr1:1,273,333–1,274,645 | 101.2 kb | Distal (>10kb) Multiome | 779 | |
| chr1:1,293,434–1,294,454 | 81.3 kb | Distal (>10kb) Multiome | 234 | |
| chr1:1,307,375–1,310,219 | 66.9 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,324,278–1,325,394 | 50.4 kb | Distal (>10kb) Multiome | 735 | |
| chr1:1,348,716–1,350,027 | 25.7 kb | Distal (>10kb) Multiome | 539 | |
| chr1:1,353,403–1,354,425 | 21.3 kb | Distal (>10kb) Multiome | 276 | |
| chr1:1,371,981–1,372,343 | 2.9 kb | Proximal (<10kb) | 371 | |
| chr1:1,374,767–1,375,798 | 174 bp | At TSS Multiome | 1113 | |
| chr1:1,398,861–1,399,955 | 24.3 kb | Distal (>10kb) Multiome | 879 | |
| chr1:1,406,992–1,407,823 | 32.1 kb | Distal (>10kb) Multiome | 938 | |
| chr1:1,435,318–1,436,066 | 60.5 kb | Distal (>10kb) Multiome | 511 | |
| chr1:1,511,442–1,512,404 | 136.8 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,540,164–1,541,317 | 165.4 kb | Distal (>10kb) Multiome | 195 | |
| chr1:1,573,904–1,575,432 | 199.6 kb | Distal (>10kb) Multiome | 949 | |
| chr1:1,599,945–1,600,642 | 224.8 kb | Distal (>10kb) Multiome | 307 | |
| chr1:1,615,103–1,616,799 | 240.3 kb | Distal (>10kb) Multiome | 951 | |
| chr1:1,628,379–1,632,529 | 254.9 kb | Distal (>10kb) Multiome | 552 | |
| chr1:1,658,722–1,659,418 | 283.9 kb | Distal (>10kb) Multiome | 602 |
Genomic view of the AURKAIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.