This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ATP6V1D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP6V1D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP6V1D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:67,240,431–67,242,037 | 118.5 kb | Distal (>10kb) Multiome | 924 | |
| chr14:67,359,034–67,360,833 | 204 bp | At TSS Multiome | 891 | |
| chr14:67,427,006–67,427,629 | 67.5 kb | Distal (>10kb) Multiome | 288 | |
| chr14:67,514,900–67,515,814 | 155.5 kb | Distal (>10kb) Multiome | 411 | |
| chr14:67,532,784–67,533,987 | 173.5 kb | Distal (>10kb) Multiome | 684 | |
| chr14:67,541,829–67,542,290 | 182.2 kb | Distal (>10kb) Multiome | 187 | |
| chr14:67,599,595–67,600,617 | 240.4 kb | Distal (>10kb) Multiome | 746 | |
| chr14:67,619,336–67,620,756 | 260.0 kb | Distal (>10kb) Multiome | 794 |
Genomic view of the ATP6V1D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.