This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ATP6V1B2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP6V1B2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP6V1B2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:19,939,255–19,940,736 | 257.7 kb | Distal (>10kb) Multiome | 357 | |
| chr8:20,196,723–20,198,840 | 1.3 kb | Proximal (<10kb) Multiome | 908 | |
| chr8:20,233,433–20,235,922 | 37.4 kb | Distal (>10kb) Multiome | 438 | |
| chr8:20,268,136–20,269,428 | 70.9 kb | Distal (>10kb) Multiome | 402 | |
| chr8:20,288,802–20,289,605 | 91.9 kb | Distal (>10kb) Multiome | 28 | |
| chr8:20,303,205–20,304,353 | 106.6 kb | Distal (>10kb) Multiome | 352 | |
| chr8:20,327,805–20,328,767 | 130.9 kb | Distal (>10kb) Multiome | 129 | |
| chr8:20,352,955–20,355,223 | 157.6 kb | Distal (>10kb) Multiome | 316 | |
| chr8:20,362,692–20,363,243 | 165.5 kb | Distal (>10kb) Multiome | 52 | |
| chr8:20,434,902–20,436,096 | 238.1 kb | Distal (>10kb) Multiome | 349 | |
| chr8:20,458,168–20,458,743 | 261.0 kb | Distal (>10kb) Multiome | 138 |
Genomic view of the ATP6V1B2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.