Transcription factors with Perturb-seq knockdown data for ATP6V0D1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP6V0D1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP6V0D1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,183,333–67,184,856 | 297.5 kb | Distal (>10kb) Multiome | 886 | |
| chr16:67,185,256–67,185,693 | 295.7 kb | Distal (>10kb) Multiome | 740 | |
| chr16:67,191,949–67,192,449 | 289.2 kb | Distal (>10kb) Multiome | 781 | |
| chr16:67,198,940–67,200,211 | 281.6 kb | Distal (>10kb) Multiome | 325 | |
| chr16:67,226,487–67,227,575 | 254.3 kb | Distal (>10kb) Multiome | 909 | |
| chr16:67,236,439–67,237,267 | 244.5 kb | Distal (>10kb) Multiome | 195 | |
| chr16:67,245,855–67,247,890 | 233.8 kb | Distal (>10kb) Multiome | 1077 | |
| chr16:67,248,206–67,249,338 | 232.2 kb | Distal (>10kb) Multiome | 467 | |
| chr16:67,262,177–67,262,869 | 218.8 kb | Distal (>10kb) Multiome | 24 | |
| chr16:67,278,724–67,279,792 | 201.9 kb | Distal (>10kb) Multiome | 869 | |
| chr16:67,326,413–67,327,343 | 154.5 kb | Distal (>10kb) Multiome | 585 | |
| chr16:67,393,199–67,393,789 | 87.8 kb | Distal (>10kb) Multiome | 377 | |
| chr16:67,399,230–67,399,872 | 81.7 kb | Distal (>10kb) Multiome | 211 | |
| chr16:67,415,996–67,416,812 | 64.9 kb | Distal (>10kb) Multiome | 687 | |
| chr16:67,428,012–67,428,783 | 53.0 kb | Distal (>10kb) Multiome | 382 | |
| chr16:67,430,407–67,432,610 | 50.2 kb | Distal (>10kb) Multiome | 790 | |
| chr16:67,480,508–67,481,841 | 75 bp | At TSS Multiome | 1002 | |
| chr16:67,489,081–67,489,305 | 7.8 kb | Proximal (<10kb) | 218 | |
| chr16:67,521,086–67,521,812 | 40.1 kb | Distal (>10kb) Multiome HiCAR | 775 | |
| chr16:67,528,470–67,529,464 | 47.5 kb | Distal (>10kb) Multiome HiCAR | 641 | |
| chr16:67,537,215–67,538,620 | 56.7 kb | Distal (>10kb) Multiome | 560 | |
| chr16:67,561,597–67,563,672 | 81.0 kb | Distal (>10kb) Multiome | 1044 | |
| chr16:67,644,719–67,645,304 | 163.6 kb | Distal (>10kb) Multiome | 638 | |
| chr16:67,649,353–67,649,999 | 168.4 kb | Distal (>10kb) Multiome | 112 | |
| chr16:67,652,610–67,653,810 | 171.7 kb | Distal (>10kb) Multiome | 498 | |
| chr16:67,659,631–67,661,707 | 179.5 kb | Distal (>10kb) Multiome HiCAR | 962 | |
| chr16:67,666,180–67,667,235 | 185.3 kb | Distal (>10kb) Multiome HiCAR | 713 | |
| chr16:67,667,674–67,668,349 | 186.8 kb | Distal (>10kb) Multiome HiCAR | 628 | |
| chr16:67,718,772–67,720,138 | 238.0 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the ATP6V0D1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.