ATP6V0C
ATPase H+ transporting V0 subunit c | VATL, Vma3, ATP6C, ATP6L, ATPL

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]

Member of: DE-1 DE-1.6
Biological processes 48 terms
Golgi lumen acidification (GO:0061795)Golgi membrane (GO:0000139)azurophil granule membrane (GO:0035577)bounding membrane of organelle (GO:0098588)cellular response to amino acid stimulus (GO:0071230)clathrin-coated vesicle membrane (GO:0030665)endosomal lumen acidification (GO:0048388)endosome membrane (GO:0010008)endosome membrane (GO:0010008)extracellular exosome (GO:0070062)ficolin-1-rich granule membrane (GO:0101003)focal adhesion (GO:0005925)guanyl nucleotide exchange factor activator activity (GO:0160124)intracellular pH reduction (GO:0051452)lysosomal lumen acidification (GO:0007042)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosomal proton-transporting V-type ATPase complex (GO:0046611)membrane (GO:0016020)membrane (GO:0016020)membrane (GO:0016020)phagocytic vesicle membrane (GO:0030670)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of TORC1 signaling (GO:1904263)positive regulation of Wnt signaling pathway (GO:0030177)protein binding (GO:0005515)proton motive force-driven ATP synthesis (GO:0015986)proton transmembrane transport (GO:1902600)proton transmembrane transport (GO:1902600)proton transmembrane transport (GO:1902600)proton transmembrane transporter activity (GO:0015078)proton transmembrane transporter activity (GO:0015078)proton-transporting ATP synthase activity, rotational mechanism (GO:0046933)proton-transporting ATPase activity, rotational mechanism (GO:0046961)proton-transporting ATPase activity, rotational mechanism (GO:0046961)proton-transporting V-type ATPase complex (GO:0033176)proton-transporting V-type ATPase, V0 domain (GO:0033179)proton-transporting two-sector ATPase complex, proton-transporting domain (GO:0033177)regulation of macroautophagy (GO:0016241)synaptic vesicle lumen acidification (GO:0097401)synaptic vesicle membrane (GO:0030672)tertiary granule membrane (GO:0070821)ubiquitin protein ligase binding (GO:0031625)vacuolar acidification (GO:0007035)vacuolar proton-transporting V-type ATPase, V0 domain (GO:0000220)
Expression (TPM)
ATP6V0C — as a Regulated Gene

TFs regulating ATP6V0C 0 TFs

Transcription factors with Perturb-seq knockdown data for ATP6V0C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP6V0C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ATP6V0C

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP6V0C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:2,205,129–2,206,297 308.4 kb Distal (>10kb) Multiome HiCAR 887
chr16:2,214,212–2,215,803 298.9 kb Distal (>10kb) Multiome 953
chr16:2,223,095–2,224,285 290.5 kb Distal (>10kb) Multiome 918
chr16:2,251,044–2,252,460 262.3 kb Distal (>10kb) Multiome 996
chr16:2,267,625–2,269,111 245.7 kb Distal (>10kb) Multiome HiCAR 1044
chr16:2,339,631–2,342,283 173.1 kb Distal (>10kb) Multiome 1129
chr16:2,428,282–2,429,948 84.7 kb Distal (>10kb) Multiome 827
chr16:2,459,524–2,460,612 53.9 kb Distal (>10kb) Multiome 670
chr16:2,467,565–2,468,324 46.1 kb Distal (>10kb) Multiome 450
chr16:2,470,913–2,472,223 42.6 kb Distal (>10kb) Multiome 427
chr16:2,473,455–2,476,127 38.8 kb Distal (>10kb) Multiome 719
chr16:2,501,124–2,501,877 12.5 kb Distal (>10kb) Multiome 471
chr16:2,513,006–2,514,809 181 bp At TSS Multiome 818
chr16:2,520,064–2,520,618 6.4 kb Proximal (<10kb) Multiome 624
chr16:2,531,456–2,533,080 18.2 kb Distal (>10kb) Multiome 883
chr16:2,537,433–2,538,433 23.9 kb Distal (>10kb) Multiome 498
chr16:2,603,176–2,603,939 89.5 kb Distal (>10kb) Multiome 1066
chr16:2,673,059–2,673,910 159.6 kb Distal (>10kb) Multiome 471
chr16:2,682,205–2,683,006 168.5 kb Distal (>10kb) Multiome 1003
chr16:2,720,741–2,721,896 207.3 kb Distal (>10kb) Multiome 758
chr16:2,751,637–2,753,398 238.6 kb Distal (>10kb) Multiome 1074
chr16:2,776,766–2,778,256 263.4 kb Distal (>10kb) Multiome 828

Genome Browser

Genomic view of the ATP6V0C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:2,195,129 – 2,788,256
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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