This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for ATP6AP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP6AP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP6AP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:154,136,648–154,137,146 | 291.8 kb | Distal (>10kb) Multiome | 391 | |
| chrX:154,368,993–154,370,053 | 59.1 kb | Distal (>10kb) Multiome | 546 | |
| chrX:154,370,757–154,372,188 | 57.3 kb | Distal (>10kb) Multiome | 764 | |
| chrX:154,378,063–154,379,701 | 49.7 kb | Distal (>10kb) Multiome | 687 | |
| chrX:154,397,430–154,398,941 | 30.4 kb | Distal (>10kb) Multiome | 871 | |
| chrX:154,409,052–154,409,671 | 19.3 kb | Distal (>10kb) Multiome | 396 | |
| chrX:154,428,419–154,428,969 | 47 bp | At TSS Multiome | 601 | |
| chrX:154,436,501–154,437,435 | 8.3 kb | Proximal (<10kb) Multiome | 448 | |
| chrX:154,443,986–154,444,454 | 15.5 kb | Distal (>10kb) Multiome | 329 | |
| chrX:154,457,605–154,458,763 | 29.4 kb | Distal (>10kb) Multiome | 467 | |
| chrX:154,478,385–154,479,590 | 50.4 kb | Distal (>10kb) Multiome | 707 | |
| chrX:154,486,385–154,487,035 | 58.1 kb | Distal (>10kb) Multiome | 437 | |
| chrX:154,490,259–154,491,245 | 62.1 kb | Distal (>10kb) Multiome | 567 | |
| chrX:154,515,811–154,517,059 | 87.7 kb | Distal (>10kb) Multiome | 590 | |
| chrX:154,546,514–154,547,906 | 118.5 kb | Distal (>10kb) Multiome | 691 |
Genomic view of the ATP6AP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.