Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for ATP5MG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP5MG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP5MG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:118,145,213–118,146,237 | 256.0 kb | Distal (>10kb) Multiome | 567 | |
| chr11:118,152,392–118,153,276 | 248.7 kb | Distal (>10kb) Multiome | 297 | |
| chr11:118,171,543–118,172,070 | 229.8 kb | Distal (>10kb) Multiome | 332 | |
| chr11:118,359,034–118,359,890 | 42.0 kb | Distal (>10kb) Multiome | 779 | |
| chr11:118,401,086–118,402,051 | 69 bp | At TSS Multiome | 732 | |
| chr11:118,434,505–118,437,761 | 34.7 kb | Distal (>10kb) Multiome | 1053 | |
| chr11:118,530,432–118,531,848 | 129.5 kb | Distal (>10kb) Multiome | 763 | |
| chr11:118,571,906–118,572,919 | 170.8 kb | Distal (>10kb) Multiome | 760 | |
| chr11:118,610,391–118,611,672 | 209.7 kb | Distal (>10kb) Multiome | 488 | |
| chr11:118,620,694–118,621,880 | 219.8 kb | Distal (>10kb) Multiome | 683 | |
| chr11:118,634,418–118,635,567 | 233.5 kb | Distal (>10kb) Multiome | 475 | |
| chr11:118,659,166–118,660,029 | 258.1 kb | Distal (>10kb) Multiome | 459 | |
| chr11:118,689,268–118,690,813 | 288.5 kb | Distal (>10kb) Multiome | 804 |
Genomic view of the ATP5MG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.