ATP5MC1
ATP synthase membrane subunit c locus 1 | ATP5G, ATP5G1

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Member of: DE-1 Developmental clusters: GC4
Biological processes 20 terms
Expression (TPM)
ATP5MC1 — as a Regulated Gene

TFs regulating ATP5MC1 0 TFs

Transcription factors with Perturb-seq knockdown data for ATP5MC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP5MC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ATP5MC1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP5MC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:48,610,274–48,610,853 282.0 kb Distal (>10kb) Multiome 450
chr17:48,671,728–48,672,690 220.3 kb Distal (>10kb) Multiome 409
chr17:48,678,104–48,678,743 214.3 kb Distal (>10kb) Multiome 453
chr17:48,718,468–48,719,563 173.9 kb Distal (>10kb) Multiome 164
chr17:48,719,708–48,720,337 172.8 kb Distal (>10kb) Multiome 181
chr17:48,722,219–48,723,762 169.8 kb Distal (>10kb) Multiome 220
chr17:48,728,286–48,729,570 163.9 kb Distal (>10kb) Multiome 376
chr17:48,816,754–48,817,592 75.6 kb Distal (>10kb) Multiome 589
chr17:48,830,670–48,831,519 61.7 kb Distal (>10kb) Multiome 838
chr17:48,891,910–48,893,540 175 bp At TSS Multiome 1059
chr17:48,907,825–48,909,317 15.5 kb Distal (>10kb) Multiome 1011
chr17:48,944,483–48,945,203 52.1 kb Distal (>10kb) Multiome 1009
chr17:48,995,124–48,997,874 104.6 kb Distal (>10kb) Multiome 1057
chr17:49,013,253–49,014,714 121.3 kb Distal (>10kb) Multiome 480
chr17:49,022,149–49,022,993 129.8 kb Distal (>10kb) Multiome 306
chr17:49,031,811–49,032,444 139.5 kb Distal (>10kb) Multiome 423
chr17:49,035,641–49,036,299 143.2 kb Distal (>10kb) Multiome 338
chr17:49,191,794–49,193,465 300.0 kb Distal (>10kb) Multiome 1177

Genome Browser

Genomic view of the ATP5MC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:48,600,274 – 49,203,465
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq