ATP13A1
ATPase 13A1 | CGI-152, FLJ31858, KIAA1825, ATP13A

Enables membrane protein dislocase activity. Involved in extraction of mislocalized protein from ER membrane. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 24 terms
ABC-type manganese transporter activity (GO:0015410)ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)ATPase-coupled monoatomic cation transmembrane transporter activity (GO:0019829)P-type ion transporter activity (GO:0015662)P-type transmembrane transporter activity (GO:0140358)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)extraction of mislocalized protein from ER membrane (GO:0140569)extraction of mislocalized protein from ER membrane (GO:0140569)intracellular calcium ion homeostasis (GO:0006874)manganese ion transmembrane transport (GO:0071421)membrane (GO:0016020)membrane (GO:0016020)membrane protein dislocase activity (GO:0140567)membrane protein dislocase activity (GO:0140567)membrane protein dislocase activity (GO:0140567)monoatomic cation transmembrane transport (GO:0098655)monoatomic ion transmembrane transport (GO:0034220)nucleotide binding (GO:0000166)protein binding (GO:0005515)transmembrane transport (GO:0055085)
Expression (TPM)
ATP13A1 — as a Regulated Gene

TFs regulating ATP13A1 0 TFs

Transcription factors with Perturb-seq knockdown data for ATP13A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP13A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ATP13A1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP13A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:19,384,944–19,386,424 278.1 kb Distal (>10kb) Multiome 788
chr19:19,405,072–19,406,890 258.0 kb Distal (>10kb) Multiome 1014
chr19:19,461,886–19,462,726 201.3 kb Distal (>10kb) Multiome 345
chr19:19,515,735–19,516,510 147.5 kb Distal (>10kb) Multiome 824
chr19:19,532,119–19,532,674 131.3 kb Distal (>10kb) Multiome 405
chr19:19,538,087–19,538,726 125.4 kb Distal (>10kb) Multiome 255
chr19:19,539,681–19,541,846 122.3 kb Distal (>10kb) Multiome 352
chr19:19,575,151–19,576,000 88.1 kb Distal (>10kb) Multiome 128
chr19:19,618,285–19,619,315 44.9 kb Distal (>10kb) Multiome 414
chr19:19,627,596–19,629,138 35.2 kb Distal (>10kb) Multiome 543
chr19:19,637,337–19,638,344 26.0 kb Distal (>10kb) Multiome 153
chr19:19,643,155–19,644,142 19.9 kb Distal (>10kb) Multiome 595
chr19:19,662,031–19,662,351 1.3 kb Proximal (<10kb) 133
chr19:19,663,091–19,664,414 228 bp At TSS Multiome 848
chr19:19,668,196–19,669,404 5.1 kb Proximal (<10kb) Multiome 778
chr19:19,669,932–19,670,337 6.3 kb Proximal (<10kb) 95
chr19:19,732,628–19,733,489 69.4 kb Distal (>10kb) Multiome 701
chr19:19,775,960–19,777,126 112.9 kb Distal (>10kb) Multiome 738
chr19:19,860,773–19,861,447 197.5 kb Distal (>10kb) Multiome HiCAR 112
chr19:19,865,643–19,866,347 202.2 kb Distal (>10kb) Multiome HiCAR 685
chr19:19,866,439–19,867,170 203.3 kb Distal (>10kb) Multiome HiCAR 306
chr19:19,900,670–19,901,891 237.2 kb Distal (>10kb) Multiome HiCAR 405

Genome Browser

Genomic view of the ATP13A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:19,374,944 – 19,911,891
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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