Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATOSA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATOSA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATOSA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:52,392,159–52,392,836 | 286.9 kb | Distal (>10kb) Multiome | 167 | |
| chr15:52,528,126–52,529,827 | 150.4 kb | Distal (>10kb) Multiome | 619 | |
| chr15:52,568,541–52,569,521 | 110.3 kb | Distal (>10kb) Multiome | 996 | |
| chr15:52,675,624–52,675,893 | 2.9 kb | Proximal (<10kb) | 12 | |
| chr15:52,677,739–52,679,973 | 86 bp | At TSS Multiome | 913 | |
| chr15:52,680,897–52,681,066 | 2.1 kb | Proximal (<10kb) | 31 | |
| chr15:52,699,116–52,699,867 | 20.2 kb | Distal (>10kb) Multiome | 140 | |
| chr15:52,709,542–52,710,221 | 30.5 kb | Distal (>10kb) Multiome | 335 | |
| chr15:52,745,306–52,746,160 | 66.4 kb | Distal (>10kb) Multiome | 166 | |
| chr15:52,783,424–52,785,757 | 104.3 kb | Distal (>10kb) Multiome | 397 | |
| chr15:52,789,439–52,791,791 | 111.0 kb | Distal (>10kb) Multiome | 633 | |
| chr15:52,798,074–52,799,220 | 119.5 kb | Distal (>10kb) Multiome | 184 | |
| chr15:52,804,516–52,806,560 | 126.4 kb | Distal (>10kb) Multiome | 322 |
Genomic view of the ATOSA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.