Enables identical protein binding activity. Involved in autophagosome assembly and negative regulation of cell population proliferation. Located in phagophore assembly site. Part of Atg1/ULK1 kinase complex. Biomarker of cholangiocarcinoma; colon cancer; and hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATG101. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATG101 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATG101, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:51,777,271–51,777,860 | 292.4 kb | Distal (>10kb) Multiome | 91 | |
| chr12:51,813,977–51,815,076 | 255.5 kb | Distal (>10kb) Multiome | 486 | |
| chr12:51,820,355–51,822,541 | 249.0 kb | Distal (>10kb) Multiome | 412 | |
| chr12:51,846,754–51,849,656 | 222.8 kb | Distal (>10kb) Multiome | 440 | |
| chr12:51,863,484–51,864,666 | 205.7 kb | Distal (>10kb) Multiome | 326 | |
| chr12:51,887,921–51,888,408 | 181.9 kb | Distal (>10kb) Multiome | 151 | |
| chr12:51,951,120–51,952,143 | 118.4 kb | Distal (>10kb) Multiome | 587 | |
| chr12:51,972,655–51,973,245 | 97.1 kb | Distal (>10kb) Multiome | 353 | |
| chr12:52,005,871–52,007,901 | 63.1 kb | Distal (>10kb) Multiome | 293 | |
| chr12:52,010,041–52,010,749 | 59.6 kb | Distal (>10kb) Multiome | 443 | |
| chr12:52,014,577–52,015,139 | 55.1 kb | Distal (>10kb) Multiome | 72 | |
| chr12:52,022,754–52,024,212 | 46.2 kb | Distal (>10kb) Multiome | 630 | |
| chr12:52,025,442–52,026,162 | 44.2 kb | Distal (>10kb) Multiome | 629 | |
| chr12:52,032,739–52,033,401 | 36.9 kb | Distal (>10kb) Multiome HiCAR | 640 | |
| chr12:52,036,744–52,037,531 | 32.8 kb | Distal (>10kb) Multiome HiCAR | 625 | |
| chr12:52,050,161–52,052,728 | 18.7 kb | Distal (>10kb) Multiome HiCAR | 861 | |
| chr12:52,069,275–52,070,473 | 225 bp | At TSS Multiome | 901 | |
| chr12:52,119,893–52,120,359 | 50.2 kb | Distal (>10kb) Multiome | 380 | |
| chr12:52,163,813–52,164,287 | 94.1 kb | Distal (>10kb) Multiome | 450 | |
| chr12:52,232,988–52,233,518 | 163.1 kb | Distal (>10kb) Multiome | 170 | |
| chr12:52,308,190–52,308,768 | 238.6 kb | Distal (>10kb) Multiome | 295 |
Genomic view of the ATG101 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.