Enables DNA clamp unloader activity. Involved in positive regulation of DNA replication and positive regulation of cell cycle G2/M phase transition. Part of Elg1 RFC-like complex. Biomarker of neurilemmoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATAD5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATAD5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATAD5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:30,599,655–30,601,277 | 234.8 kb | Distal (>10kb) Multiome | 793 | |
| chr17:30,707,918–30,709,425 | 126.6 kb | Distal (>10kb) Multiome | 471 | |
| chr17:30,731,337–30,732,077 | 103.6 kb | Distal (>10kb) Multiome | 352 | |
| chr17:30,824,074–30,825,310 | 10.5 kb | Distal (>10kb) Multiome | 868 | |
| chr17:30,825,798–30,826,217 | 5.8 kb | Proximal (<10kb) | 303 | |
| chr17:30,831,761–30,832,403 | 3.2 kb | Proximal (<10kb) Multiome | 803 | |
| chr17:30,906,142–30,906,858 | 71.2 kb | Distal (>10kb) Multiome | 1033 | |
| chr17:30,921,825–30,922,307 | 86.9 kb | Distal (>10kb) Multiome | 262 | |
| chr17:30,970,780–30,971,531 | 135.9 kb | Distal (>10kb) Multiome | 537 | |
| chr17:31,008,384–31,008,968 | 173.4 kb | Distal (>10kb) Multiome | 415 | |
| chr17:31,094,330–31,095,946 | 259.7 kb | Distal (>10kb) Multiome | 759 |
Genomic view of the ATAD5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.