The protein encoded by this gene is localized to the mitochondrial inner membrane, where it can bind to a highly-related protein, ATAD3A. ATAD3A appears to interact with matrix nucleoid complexes, and the encoded protein negatively regulates that interaction. This gene is expressed almost exclusively in pluripotent embryonic stem cells and some cancer cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for ATAD3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATAD3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATAD3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:1,231,448–1,233,390 | 239.6 kb | Distal (>10kb) Multiome | 884 | |
| chr1:1,273,333–1,274,645 | 197.8 kb | Distal (>10kb) Multiome | 779 | |
| chr1:1,293,434–1,294,454 | 177.8 kb | Distal (>10kb) Multiome | 234 | |
| chr1:1,307,375–1,310,219 | 163.5 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,324,278–1,325,394 | 147.0 kb | Distal (>10kb) Multiome | 735 | |
| chr1:1,348,716–1,350,027 | 122.3 kb | Distal (>10kb) Multiome | 539 | |
| chr1:1,353,403–1,354,425 | 117.9 kb | Distal (>10kb) Multiome | 276 | |
| chr1:1,374,767–1,375,798 | 96.4 kb | Distal (>10kb) Multiome | 1113 | |
| chr1:1,398,861–1,399,955 | 72.3 kb | Distal (>10kb) Multiome | 879 | |
| chr1:1,406,992–1,407,823 | 64.4 kb | Distal (>10kb) Multiome | 938 | |
| chr1:1,435,318–1,436,066 | 36.1 kb | Distal (>10kb) Multiome | 511 | |
| chr1:1,471,574–1,471,830 | at TSS | At TSS | 616 | |
| chr1:1,511,442–1,512,404 | 40.3 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,540,164–1,541,317 | 68.9 kb | Distal (>10kb) Multiome | 195 | |
| chr1:1,573,904–1,575,432 | 103.0 kb | Distal (>10kb) Multiome | 949 | |
| chr1:1,599,945–1,600,642 | 128.3 kb | Distal (>10kb) Multiome | 307 | |
| chr1:1,615,103–1,616,799 | 143.8 kb | Distal (>10kb) Multiome | 951 | |
| chr1:1,628,379–1,632,529 | 158.4 kb | Distal (>10kb) Multiome | 552 | |
| chr1:1,658,722–1,659,418 | 187.4 kb | Distal (>10kb) Multiome | 602 | |
| chr1:1,724,054–1,724,738 | 252.7 kb | Distal (>10kb) Multiome | 631 |
Genomic view of the ATAD3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.