Enables K63-linked polyubiquitin modification-dependent protein binding activity. Involved in regulation of DNA-templated transcription; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of DNA repair complex and RQC-trigger complex. Is active in cytosolic ribosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ASCC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ASCC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ASCC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:29,553,345–29,553,988 | 284.5 kb | Distal (>10kb) Multiome | 837 | |
| chr22:29,580,084–29,581,520 | 257.2 kb | Distal (>10kb) Multiome | 856 | |
| chr22:29,603,006–29,604,162 | 234.8 kb | Distal (>10kb) Multiome | 803 | |
| chr22:29,766,399–29,767,654 | 71.2 kb | Distal (>10kb) Multiome | 837 | |
| chr22:29,837,985–29,838,559 | 84 bp | At TSS Multiome | 690 | |
| chr22:29,882,926–29,883,914 | 44.9 kb | Distal (>10kb) Multiome | 628 | |
| chr22:30,079,923–30,080,552 | 242.1 kb | Distal (>10kb) Multiome | 167 |
Genomic view of the ASCC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.