This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for ASAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ASAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ASAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:130,203,971–130,204,947 | 239.2 kb | Distal (>10kb) Multiome | 170 | |
| chr8:130,357,173–130,359,336 | 85.0 kb | Distal (>10kb) Multiome | 681 | |
| chr8:130,424,188–130,424,853 | 19.2 kb | Distal (>10kb) Multiome | 115 | |
| chr8:130,442,854–130,444,273 | 2 bp | At TSS Multiome | 728 | |
| chr8:130,518,596–130,519,515 | 75.3 kb | Distal (>10kb) Multiome | 373 | |
| chr8:130,527,835–130,528,626 | 84.5 kb | Distal (>10kb) Multiome | 433 | |
| chr8:130,688,062–130,688,754 | 244.8 kb | Distal (>10kb) Multiome | 44 |
Genomic view of the ASAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.