Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for ARSK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARSK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARSK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:95,283,233–95,285,856 | 270.9 kb | Distal (>10kb) Multiome | 620 | |
| chr5:95,439,846–95,441,190 | 114.9 kb | Distal (>10kb) Multiome | 213 | |
| chr5:95,554,418–95,555,610 | 82 bp | At TSS Multiome | 886 | |
| chr5:95,619,877–95,621,756 | 66.2 kb | Distal (>10kb) Multiome | 693 | |
| chr5:95,646,204–95,647,493 | 91.7 kb | Distal (>10kb) Multiome | 938 | |
| chr5:95,668,883–95,670,237 | 114.5 kb | Distal (>10kb) Multiome | 232 | |
| chr5:95,707,140–95,707,835 | 152.5 kb | Distal (>10kb) Multiome | 297 | |
| chr5:95,710,009–95,710,708 | 155.3 kb | Distal (>10kb) Multiome | 190 | |
| chr5:95,710,983–95,712,019 | 156.5 kb | Distal (>10kb) Multiome | 238 | |
| chr5:95,730,766–95,732,378 | 176.1 kb | Distal (>10kb) Multiome | 1009 | |
| chr5:95,822,039–95,823,085 | 267.4 kb | Distal (>10kb) Multiome | 509 | |
| chr5:95,823,341–95,824,963 | 269.3 kb | Distal (>10kb) Multiome | 644 | |
| chr5:95,834,672–95,835,242 | 279.9 kb | Distal (>10kb) Multiome | 673 |
Genomic view of the ARSK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.