The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for ARSG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARSG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARSG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:67,993,084–67,994,333 | 297.8 kb | Distal (>10kb) Multiome | 896 | |
| chr17:68,019,469–68,020,645 | 271.4 kb | Distal (>10kb) Multiome | 1154 | |
| chr17:68,033,975–68,034,637 | 257.3 kb | Distal (>10kb) Multiome | 288 | |
| chr17:68,035,094–68,036,341 | 255.9 kb | Distal (>10kb) Multiome | 1009 | |
| chr17:68,101,069–68,102,208 | 189.9 kb | Distal (>10kb) Multiome | 934 | |
| chr17:68,169,087–68,169,738 | 122.0 kb | Distal (>10kb) Multiome | 34 | |
| chr17:68,195,930–68,196,516 | 95.3 kb | Distal (>10kb) Multiome | 132 | |
| chr17:68,198,840–68,199,804 | 92.1 kb | Distal (>10kb) Multiome | 254 | |
| chr17:68,200,632–68,201,332 | 90.5 kb | Distal (>10kb) Multiome | 510 | |
| chr17:68,205,092–68,206,268 | 86.0 kb | Distal (>10kb) Multiome | 867 | |
| chr17:68,247,371–68,248,543 | 43.5 kb | Distal (>10kb) Multiome | 986 | |
| chr17:68,290,404–68,290,958 | 535 bp | At TSS | 510 | |
| chr17:68,291,089–68,292,878 | 55 bp | At TSS Multiome | 972 | |
| chr17:68,296,240–68,296,519 | 4.7 kb | Proximal (<10kb) | 86 | |
| chr17:68,301,210–68,301,967 | 9.7 kb | Proximal (<10kb) | 202 | |
| chr17:68,456,319–68,458,376 | 166.2 kb | Distal (>10kb) Multiome HiCAR | 914 | |
| chr17:68,462,644–68,463,284 | 171.6 kb | Distal (>10kb) Multiome | 394 | |
| chr17:68,511,401–68,513,461 | 220.9 kb | Distal (>10kb) Multiome | 1112 |
Genomic view of the ARSG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.