The protein encoded by this gene is a member of the sulfatase family. Sulfatases are essential for the correct composition of bone and cartilage matrix. The encoded protein is postranslationally glycosylated and localized to the lysosome. This gene is located within a cluster of similar arylsulfatase genes on chromosome X. A related pseudogene has been identified in the pseudoautosomal region of chromosome Y. [provided by RefSeq, Jul 2011]
Transcription factors with Perturb-seq knockdown data for ARSD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARSD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARSD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:2,828,742–2,829,221 | 100.4 kb | Distal (>10kb) Multiome | 197 | |
| chrX:2,891,906–2,892,349 | 37.3 kb | Distal (>10kb) Multiome | 79 | |
| chrX:2,897,439–2,898,349 | 31.4 kb | Distal (>10kb) Multiome | 192 | |
| chrX:2,926,136–2,926,525 | 2.8 kb | Proximal (<10kb) | 9 | |
| chrX:2,927,517–2,929,497 | 678 bp | At TSS Multiome | 582 |
Genomic view of the ARSD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.