Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for ARSB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARSB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARSB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:78,647,879–78,649,652 | 336.5 kb | Distal (>10kb) Multiome HiCAR | 642 | |
| chr5:78,689,782–78,690,552 | 295.1 kb | Distal (>10kb) Multiome | 97 | |
| chr5:78,771,124–78,771,783 | 213.9 kb | Distal (>10kb) Multiome | 183 | |
| chr5:78,907,698–78,908,761 | 76.9 kb | Distal (>10kb) Multiome HiCAR | 489 | |
| chr5:78,927,570–78,928,199 | 57.5 kb | Distal (>10kb) Multiome | 249 | |
| chr5:78,984,328–78,985,552 | 501 bp | At TSS Multiome | 723 | |
| chr5:79,133,486–79,134,197 | 148.6 kb | Distal (>10kb) Multiome | 405 | |
| chr5:79,181,446–79,182,087 | 196.5 kb | Distal (>10kb) Multiome | 128 | |
| chr5:79,201,015–79,202,117 | 216.3 kb | Distal (>10kb) Multiome | 171 | |
| chr5:79,235,642–79,237,807 | 250.8 kb | Distal (>10kb) Multiome | 860 |
Genomic view of the ARSB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.