Transcription factors with Perturb-seq knockdown data for ARRDC3-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARRDC3-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARRDC3-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:91,279,530–91,281,166 | 99.7 kb | Distal (>10kb) Multiome | 1014 | |
| chr5:91,379,787–91,382,325 | 106 bp | At TSS Multiome | 962 | |
| chr5:91,382,531–91,384,285 | 3.1 kb | Proximal (<10kb) Multiome | 878 | |
| chr5:91,384,929–91,385,186 | 4.6 kb | Proximal (<10kb) | 335 |
Genomic view of the ARRDC3-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.