The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]
Transcription factors with Perturb-seq knockdown data for ARPP19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARPP19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARPP19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:52,294,913–52,296,036 | 273.3 kb | Distal (>10kb) Multiome | 630 | |
| chr15:52,392,159–52,392,836 | 176.5 kb | Distal (>10kb) Multiome | 167 | |
| chr15:52,528,126–52,529,827 | 40.0 kb | Distal (>10kb) Multiome | 619 | |
| chr15:52,568,541–52,569,521 | 42 bp | At TSS Multiome | 996 | |
| chr15:52,677,739–52,679,973 | 110.4 kb | Distal (>10kb) Multiome | 913 | |
| chr15:52,699,116–52,699,867 | 130.6 kb | Distal (>10kb) Multiome | 140 | |
| chr15:52,709,542–52,710,221 | 140.8 kb | Distal (>10kb) Multiome | 335 | |
| chr15:52,745,306–52,746,160 | 176.8 kb | Distal (>10kb) Multiome | 166 | |
| chr15:52,783,424–52,785,757 | 214.6 kb | Distal (>10kb) Multiome | 397 | |
| chr15:52,789,439–52,791,791 | 221.4 kb | Distal (>10kb) Multiome | 633 | |
| chr15:52,798,074–52,799,220 | 229.9 kb | Distal (>10kb) Multiome | 184 | |
| chr15:52,804,516–52,806,560 | 236.7 kb | Distal (>10kb) Multiome | 322 |
Genomic view of the ARPP19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.