This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for ARPC1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARPC1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARPC1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:99,142,006–99,144,629 | 232.3 kb | Distal (>10kb) Multiome | 865 | |
| chr7:99,325,304–99,326,401 | 48.8 kb | Distal (>10kb) Multiome | 858 | |
| chr7:99,373,955–99,375,619 | 818 bp | At TSS Multiome | 759 | |
| chr7:99,392,361–99,394,025 | 18.5 kb | Distal (>10kb) Multiome | 486 | |
| chr7:99,407,975–99,409,432 | 34.1 kb | Distal (>10kb) Multiome | 975 | |
| chr7:99,438,371–99,439,668 | 64.4 kb | Distal (>10kb) Multiome | 881 | |
| chr7:99,465,842–99,466,381 | 91.4 kb | Distal (>10kb) Multiome | 949 | |
| chr7:99,471,690–99,473,325 | 98.1 kb | Distal (>10kb) Multiome | 861 | |
| chr7:99,499,759–99,500,629 | 125.6 kb | Distal (>10kb) Multiome | 809 | |
| chr7:99,504,224–99,505,507 | 130.1 kb | Distal (>10kb) Multiome | 881 | |
| chr7:99,557,927–99,559,319 | 183.9 kb | Distal (>10kb) Multiome | 922 | |
| chr7:99,580,108–99,580,792 | 205.7 kb | Distal (>10kb) Multiome | 296 | |
| chr7:99,616,474–99,617,353 | 242.1 kb | Distal (>10kb) Multiome | 1043 | |
| chr7:99,693,257–99,693,867 | 318.8 kb | Distal (>10kb) Multiome | 518 |
Genomic view of the ARPC1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.