This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for ARPC1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARPC1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARPC1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:99,142,006–99,144,629 | 183.6 kb | Distal (>10kb) Multiome | 865 | |
| chr7:99,325,304–99,326,401 | 56 bp | At TSS Multiome | 858 | |
| chr7:99,373,955–99,375,619 | 49.6 kb | Distal (>10kb) Multiome | 759 | |
| chr7:99,392,361–99,394,025 | 67.3 kb | Distal (>10kb) Multiome | 486 | |
| chr7:99,407,975–99,409,432 | 82.9 kb | Distal (>10kb) Multiome | 975 | |
| chr7:99,438,371–99,439,668 | 113.1 kb | Distal (>10kb) Multiome | 881 | |
| chr7:99,465,842–99,466,381 | 140.2 kb | Distal (>10kb) Multiome | 949 | |
| chr7:99,471,690–99,473,325 | 146.9 kb | Distal (>10kb) Multiome | 861 | |
| chr7:99,499,759–99,500,629 | 174.4 kb | Distal (>10kb) Multiome | 809 | |
| chr7:99,504,224–99,505,507 | 178.8 kb | Distal (>10kb) Multiome | 881 | |
| chr7:99,557,927–99,559,319 | 232.7 kb | Distal (>10kb) Multiome | 922 | |
| chr7:99,580,108–99,580,792 | 254.5 kb | Distal (>10kb) Multiome | 296 | |
| chr7:99,616,474–99,617,353 | 290.9 kb | Distal (>10kb) Multiome | 1043 |
Genomic view of the ARPC1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.