Predicted to enable TORC2 complex binding activity. Involved in regulation of inflammatory response. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARMH4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARMH4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARMH4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:57,865,076–57,866,413 | 432.5 kb | Distal (>10kb) Multiome | 315 | |
| chr14:58,151,365–58,152,866 | 145.9 kb | Distal (>10kb) Multiome | 506 | |
| chr14:58,199,683–58,200,642 | 98.1 kb | Distal (>10kb) Multiome | 673 | |
| chr14:58,244,179–58,245,432 | 53.3 kb | Distal (>10kb) Multiome | 789 | |
| chr14:58,297,373–58,299,879 | 87 bp | At TSS Multiome | 1029 | |
| chr14:58,395,454–58,396,694 | 97.9 kb | Distal (>10kb) Multiome | 791 | |
| chr14:58,426,724–58,428,061 | 129.5 kb | Distal (>10kb) Multiome | 996 |
Genomic view of the ARMH4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.