The product of this gene belongs to the armadillo repeat-containing family of proteins, which interact with other proteins in a variety of cellular processes. The function of this family member is currently unknown. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for ARMCX4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARMCX4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARMCX4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:101,348,449–101,349,149 | 69.4 kb | Distal (>10kb) Multiome | 567 | |
| chrX:101,390,531–101,391,386 | 27.3 kb | Distal (>10kb) Multiome | 762 | |
| chrX:101,407,491–101,408,749 | 10.2 kb | Distal (>10kb) Multiome | 745 | |
| chrX:101,415,556–101,415,814 | 2.5 kb | Proximal (<10kb) | 120 | |
| chrX:101,417,975–101,418,807 | 110 bp | At TSS Multiome | 296 | |
| chrX:101,484,988–101,486,015 | 67.1 kb | Distal (>10kb) Multiome | 155 | |
| chrX:101,550,213–101,551,613 | 132.3 kb | Distal (>10kb) Multiome | 249 | |
| chrX:101,617,258–101,618,125 | 199.4 kb | Distal (>10kb) Multiome | 435 | |
| chrX:101,622,792–101,623,603 | 204.8 kb | Distal (>10kb) Multiome | 410 |
Genomic view of the ARMCX4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.