This gene encodes a protein containing a potential N-terminal transmembrane domain and multiple armadillo (arm) repeats. Proteins containing arm repeats are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is located in a cluster of related genes on chromosome X. There is a pseudogene for this gene on chromosome 7. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for ARMCX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARMCX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARMCX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:101,390,531–101,391,386 | 268.9 kb | Distal (>10kb) Multiome | 762 | |
| chrX:101,407,491–101,408,749 | 251.7 kb | Distal (>10kb) Multiome | 745 | |
| chrX:101,417,975–101,418,807 | 241.5 kb | Distal (>10kb) Multiome | 296 | |
| chrX:101,484,988–101,486,015 | 174.4 kb | Distal (>10kb) Multiome | 155 | |
| chrX:101,550,213–101,551,613 | 109.2 kb | Distal (>10kb) Multiome | 249 | |
| chrX:101,617,258–101,618,125 | 42.2 kb | Distal (>10kb) Multiome | 435 | |
| chrX:101,622,792–101,623,603 | 36.7 kb | Distal (>10kb) Multiome | 410 | |
| chrX:101,658,629–101,660,026 | at TSS | At TSS | 284 | |
| chrX:101,931,243–101,932,294 | 272.0 kb | Distal (>10kb) Multiome | 551 |
Genomic view of the ARMCX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.